AACR Journals

Abstract P4-02-01: Targeting insulin receptor in estrogen receptor positive breast cancer

Abstract: Obesity and metabolic dysfunction are on the rise in the United States. Hyperinsulinemia, frequently seen in these conditions, correlates with an increased risk of development and mortality from estrogen receptor (ER) positive breast cancer. Expression of components of the insulin and insulin-like growth factor (IGF) family of proteins promote cancer cell growth in vitro, link to shorter progression-free survival, and is associates with an increased risk of metastatic disease and death in breast cancer patients.

Read the full abstract on AACRJournals.org


 

 

Journal for Veterinary Internal Medicine (via Wiley Online Library)

Ultra-long-acting recombinant insulin for the treatment of diabetes mellitus in dogs

Background: For the treatment of diabetes mellitus (DM) in dogs, novel insulins with decreased injection frequency while maintaining safety and efficacy are desirable. Insulin fused with immunoglobulin-fragment-crystallizable (Fc) has an ultra-long plasma half-life because it recycles through cells, protected from proteolysis.

Read the paper on Wiley Online Library


 

Published in ScienceDirect

Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452

AKS-452 is a biologically-engineered vaccine comprising an Fc fusion protein of the SARS-CoV-2 viral spike protein receptor binding domain antigen (Ag) and human IgG1 Fc (SP/RBD-Fc) in clinical development for the induction and augmentation of neutralizing IgG titers against SARS-CoV-2 viral infection to address the COVID-19 pandemic.

Read the paper on ScienceDirect.com


Published in the National Center for Biotechnology Information

Disrupting Insulin and IGF Receptor Function in Cancer

The insulin and insulin-like growth factor (IGF) system plays an important role in regulating normal cell proliferation and survival. However, the IGF system is also implicated in many malignancies, including breast cancer. Preclinical studies indicate several IGF blocking approaches, such as monoclonal antibodies and tyrosine kinase inhibitors, have promising therapeutic potential for treating diseases.

Read the paper on the NCBI website


Published in ResearchGate

Abstract P1-21-05: A novel long-acting insulin for cancer therapy reduces xenograft tumor growth

A link between obesity, metabolic dysfunction, and an increased risk in cancer mortality has been well established in several cancer types including, breast, colon, pancreatic, and prostate cancers. A likely mechanism driving this elevated risk is the associated increase in circulating insulin and insulin-like growth factor (IGF), which are known promoters of cancer growth and have been linked to shorter progression-free survival, and increased risk of metastatic disease and death in breast cancer patients. IGF receptor (IGF1R) targeting has been unsuccessful as insulin receptor (IR) also is functional in breast cancers.

 

Read the paper on ResearchGate.com


Published in the Journal of Veterinary Internal Medicine

An ultra-long-acting recombinant insulin for the treatment of diabetes mellitus in cats

Treatment of diabetes mellitus (DM) in cats typically requires insulin injections q12h-q24h, posing a major compliance barrier for caregivers. Novel treatments enabling decreased injection frequency while maintaining safety are highly desirable. Insulin fused with feline immunoglobulin fragment crystallizable (Fc) has an ultra-long plasma half-life because it recycles through cells where it is protected from proteolysis.

Read the paper on the Online Library